Maria Fomicheva
Graduate Student
Ian Macara Lab

Record History
Added on September 8, 2017 at 2:23 PM by Uttz, Pam
Modified on October 13, 2017 at 2:23 PM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time October 18, 2017 at 9:00 AM
End Date / Time October 18, 2017 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name Maria Fomicheva
Presentation Title A CRISPR Screen to Identify Mechanisms of Density Control in Mammary Epithelia
Status This meeting has already occurred

Meeting Agenda/Notes

Epithelial cell proliferation control is critical for both normal embryonic development as well as maintenance of tissue integrity. Tissues must discern when an appropriate cell density has been achieved and halt proliferation to prevent overgrowth. Nevertheless, the mechanisms that modulate epithelial cell density remain poorly understood. To identify novel genes required for density-dependent cell cycle arrest in epithelial cells, I performed a CRISPR-Cas9 whole-genome loss-of-function screen. This screen revealed a list of candidate genes that are required for proliferation control. I am currently trying to identify a mechanistic relationship between these candidate genes and cell density. This study identifies novel regulators of homeostatic cell density establishment, which deepens our understanding of epithelial cell density control and provides insights for potential cancer prevention strategies.


Document Spring_2017_Email_Notice_Fomicheva.pdf - Added on October 13, 2017 at 2:23 PM by Pam Uttz