Kenyi Saito-Diaz, Ph.D.
Postdoctoral Fellow
Ethan Lee Lab

Keywords: vcscb SPRING seminar

Record History
Added on September 8, 2017 at 2:22 PM by Uttz, Pam
Modified on September 14, 2017 at 11:02 AM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time September 20, 2017 at 9:00 AM
End Date / Time September 20, 2017 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name Kenyi Saito-Diaz, Ph.D.
Presentation Title The tumor suppressor APC regulates Wnt receptor activation
Status This meeting has already occurred

Meeting Agenda/Notes

Mutations in the APC gene leading to constitutive Wnt pathway activation occur in over 80% of human colorectal cancers. Despite its importance in tumor progression, the role of APC in the Wnt pathway is not fully understood. We provide evidence supporting a model in which APC functions as a gatekeeper to block receptor activation via the clathrin endocytic pathway. Thus, our studies reveal a new mechanism by which the Wnt pathway is aberrantly activated upon APC loss and offer insight for the development of novel therapeutics targeting Wnt-driven cancers.