|Start Date / Time||September 20, 2017 at 9:00 AM|
|End Date / Time||September 20, 2017 at 10:00 AM|
|Location||9455 MRB IV|
|Presenter Name||Kenyi Saito-Diaz, Ph.D.|
|Presentation Title||The tumor suppressor APC regulates Wnt receptor activation|
|Status||This meeting has already occurred|
Mutations in the APC gene leading to constitutive Wnt pathway activation occur in over 80% of human colorectal cancers. Despite its importance in tumor progression, the role of APC in the Wnt pathway is not fully understood. We provide evidence supporting a model in which APC functions as a gatekeeper to block receptor activation via the clathrin endocytic pathway. Thus, our studies reveal a new mechanism by which the Wnt pathway is aberrantly activated upon APC loss and offer insight for the development of novel therapeutics targeting Wnt-driven cancers.