Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.


Keywords: beta cell

Record History
Added on June 28, 2017 at 11:51 AM by Brown, Deborah
Modified on October 19, 2017 at 12:24 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Talk Master

Meeting Details

Start Date / Time October 25, 2017 at 9:00 AM
End Date / Time October 25, 2017 at 9:55 PM
Duration 12 hour(s) 55 minutes
Presenter Name Patrick Hu, MD, PhD (Medicine; Cell & Dev Biol
Presentation Title "Using the nematode C. elegans to reveal insights into insulin biogenesis"
Status This meeting has already occurred

Meeting Agenda/Notes

The discovery that missense mutations in the insulin gene cause congenital diabetes has revealed a role for early events in insulin biogenesis in metabolic homeostasis. However, the mechanisms that govern these events remain poorly understood. We have used the nematode Caenorhabditis elegans to illuminate the potential importance of a conserved transmembrane endoplasmic reticulum (ER) protein complex in the translocation of preproinsulin into the ER. Our findings highlight the utility of unbiased approaches in studying insulin signaling and implicate dysregulation of preproinsulin translocation as a possible contributor to diabetes pathogenesis.