|Start Date / Time||October 25, 2017 at 9:00 AM|
|End Date / Time||October 25, 2017 at 9:55 PM|
|Duration||12 hour(s) 55 minutes|
|Location||206 PRB (NOTE CHANGE IN ROOM)|
|Presenter Name||Patrick Hu, MD, PhD (Medicine; Cell & Dev Biol|
|Presentation Title||"Using the nematode C. elegans to reveal insights into insulin biogenesis"|
|Status||This meeting has already occurred|
The discovery that missense mutations in the insulin gene cause congenital diabetes has revealed a role for early events in insulin biogenesis in metabolic homeostasis. However, the mechanisms that govern these events remain poorly understood. We have used the nematode Caenorhabditis elegans to illuminate the potential importance of a conserved transmembrane endoplasmic reticulum (ER) protein complex in the translocation of preproinsulin into the ER. Our findings highlight the utility of unbiased approaches in studying insulin signaling and implicate dysregulation of preproinsulin translocation as a possible contributor to diabetes pathogenesis.