|Start Date / Time||September 27, 2017 at 9:00 AM|
|End Date / Time||September 27, 2017 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Leslie Roteta Sedgeman (Vicker's lab)|
|Presentation Title||Exploring the export mechanisms of pancreatic-originating HDL-microRNAs|
|Status||This meeting is currently scheduled|
A brief description of my work: microRNAs (miRNAs) are powerful regulators of glucose metabolism and function in many cell types to regulate cellular processes. miRNAs have also been found to be present in extracellular fluids: bound to lipoproteins, RNA-binding proteins, exosomes and microvesicles. Despite their potential as biomarkers and molecules in cell-to-cell communication, the cell-types and the mechanisms that control the release of miRNAs to HDL have not been elucidated. My work highlights that pancreatic beta cells contribute microRNAs, particularly miR-375, to HDL, and that this export is likely regulated by similar mechanisms that control insulin secretion from the beta cell.