|Start Date / Time||September 13, 2017 at 9:00 AM|
|End Date / Time||September 13, 2017 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Danielle Dean, PhD (Powers' laboratory)|
|Presentation Title||The hepatic-alpha cell axis|
|Status||This meeting has already occurred|
Recently, we demonstrated that when glucagon signaling is interrupted in the liver, hyperaminoacidemia (e.g. high L-glutamine) selectively stimulates alpha cell proliferation in the islet. Since L-glutamine and other amino acids also stimulate glucagon secretion, we hypothesize that hyperaminoacidemia-driven α-cell proliferation and glucagon secretion results from a high capacity for transport, metabolism, and sensing of L-glutamine and other amino acids. I will describe our current efforts to understand these mechanisms.