|Start Date / Time||August 16, 2017 at 9:00 AM|
|End Date / Time||August 16, 2017 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Karin Bosma (O'Brien's laboratory)|
|Presentation Title||Exploring the Function of G6pc2 in Pancreatic Islets|
|Status||This meeting has already occurred|
Elevated fasting blood glucose (FBG) levels have been associated with an increased risk of type 2 diabetes (T2D) development and cardiovascular-associated mortality (CAM). Genome-wide association studies (GWAS) have identified SNPs in G6PC2, an isoform of the glucose-6-phosphatase catalytic subunit expressed in pancreatic islet beta cells, that are associated with variations in FBG. Deletion of G6pc2 in mice results in reduced FBG, consistent with the human GWAS data. I am using several mouse models to further explore the function of G6pc2 in islet beta cells and its potential as a therapeutic target for the prevention of T2D and CAM.