Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.


Keywords: islet beta cell

Record History
Added on January 13, 2017 at 11:08 AM by Brown, Deborah
Modified on April 21, 2017 at 7:13 AM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Master

Meeting Details

Start Date / Time April 26, 2017 at 9:00 AM
End Date / Time April 26, 2017 at 9:55 AM
Duration 55 minutes
Location 206 Preston Research Building
Presenter Name Diane Saunders (Powers' laboratory)
Presentation Title Endothelial cells in the islet microenvironment promote β-cell proliferation
Status This meeting has already occurred

Meeting Agenda/Notes

Pancreatic islets are highly vascularized, highly innervated mini-organs in which the local islet microenvironment of endocrine cells, endothelial cells, macrophages, and extracellular matrix interact and play critical roles in β-cell mass and function. Our group has shown that bone marrow-derived macrophages recruited to pancreatic islets are required for β-cell regeneration, and we are further interrogating this process by determining the role of proliferating and quiescent endothelial cell signaling in macrophage recruitment and subsequent β-cell regeneration.  We are also extending these studies to human islets, which differ considerably from rodent islets, by investigating the structural and transcriptional changes in human intra-islet endothelial cells with aging and determining their role in human β-cell proliferation.