|Start Date / Time||April 26, 2017 at 9:00 AM|
|End Date / Time||April 26, 2017 at 9:55 AM|
|Location||206 Preston Research Building|
|Presenter Name||Diane Saunders (Powers' laboratory)|
|Presentation Title||Endothelial cells in the islet microenvironment promote β-cell proliferation|
|Status||This meeting has already occurred|
Pancreatic islets are highly vascularized, highly innervated mini-organs in which the local islet microenvironment of endocrine cells, endothelial cells, macrophages, and extracellular matrix interact and play critical roles in β-cell mass and function. Our group has shown that bone marrow-derived macrophages recruited to pancreatic islets are required for β-cell regeneration, and we are further interrogating this process by determining the role of proliferating and quiescent endothelial cell signaling in macrophage recruitment and subsequent β-cell regeneration. We are also extending these studies to human islets, which differ considerably from rodent islets, by investigating the structural and transcriptional changes in human intra-islet endothelial cells with aging and determining their role in human β-cell proliferation.