Gregor Neuert, Ph.D.
Assistant Professor of Molecular Physiology and Biophysics,
Pharmacology, and Biomedical Engineering

Keywords: vcscb SPRING seminar

Record History
Added on January 11, 2017 at 11:42 AM by Uttz, Pam
Modified on March 31, 2017 at 12:05 PM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time April 5, 2017 at 9:00 AM
End Date / Time April 5, 2017 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name Gregor Neuert, Ph.D.
Presentation Title Temporal control of cellular phenotypes
Status This meeting has already occurred

Meeting Agenda/Notes

Many biological processes are driven by gradually and temporally changing environments resulting in cell signaling and gene expression responses which are often malfunction in human diseases.  How cells sense, transmit and phenotypically respond to these temporally changing environmental signals in comparison to rapidly or acute changing environment is mostly unknown.  Here we demonstrate that a repetitive linear stress gradient but not a step, pulse or a quadratic gradient of the same intensity causes a severe cell growth phenotype. Although single cells physically sense the stress gradient, they are not protected from such a temporal stress.  We identified a gradient sensing threshold as the mechanism that prevent the Stress Activated Protein Kinase (p38 / Hog1 SAPK) pathway to active single cell signal transduction, single cell mRNA transcription and lack of cellular osmolyte production.  We demonstrate that cells can be protected against such a temporal stress through short and prior induction of permanently phosphorylated SAPK.  Our approach is general because it allows to interrogate biological phenotypes under physiologically relevant temporal conditions.

Attachment

Document Spring_2017_Email_Notice_Neuert.pdf - Added on March 31, 2017 at 12:05 PM by Pam Uttz