Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: Beta cell Islet

Record History
Added on September 7, 2016 at 4:49 PM by Brown, Deborah
Modified on December 2, 2016 at 8:31 AM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Master

Meeting Details

Start Date / Time December 7, 2016 at 9:00 AM
End Date / Time December 7, 2016 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Nicholas C. Vierra (Jacobson lab)
Presentation Title TALK-1 K+ flux controls the unique oscillatory signature of beta-cell ER calcium handling
Status This meeting has already occurred

Meeting Agenda/Notes

The type 2-diabetes associated K+ channel TALK-1 is the most highly expressed K+ channel in the islet, where it limits beta-cell cytosolic Ca2+ (Ca2+c) oscillations and insulin secretion. However, the mechanisms by which it modulates Ca2+ oscillations are unclear. Furthermore, its role in other islet cell types has not been determined. Using a variety of transgenic mice, Ca2+ sensors, and heterologous expression systems, we have discovered that TALK-1 channels serve a critical role in controlling beta-cell endoplasmic reticulum (ER) Ca2+ handling. Additionally, we have found that TALK-1 regulates delta-cell Ca2+c and somatostatin secretion, providing a paracrine signalling mechanism to control alpha-cell function. Importantly, altered TALK-1 function may perturb islet-cell ER Ca2+ homeostasis and paracrine signalling mechanisms, which can affect hormone release and contribute to disease pathogenesis.