Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: Beta cell Islet

Record History
Added on September 7, 2016 at 4:37 PM by Brown, Deborah
Modified on November 4, 2016 at 12:15 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Master

Meeting Details

Start Date / Time November 9, 2016 at 9:00 AM
End Date / Time November 9, 2016 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Hannah Worchel (Magnuson lab)
Presentation Title Pancreatic Inflammation Redirects Acinar to Beta Cell Reprogramming
Status This meeting has already occurred

Meeting Agenda/Notes

Adenoviral delivery of Pdx1, Neurog3 and MafA (3TF) to the pancreas of mice has been shown to reprogram pancreatic acinar cells into insulin-expressing beta-like cells. However, for pancreatic cellular reprogramming to ever become a viable human therapy, a greater understanding of the factors that both promote and limit reprogramming as well as the affects that acinar to beta-cell conversion has on pancreas histology and physiology is required. Using a novel mouse model that expresses 3TF in both a pancreatic acinar cell- and doxycycline-dependent manner, we discovered that the outcome of transcription factor-mediated acinar to beta-cell reprogramming is highly dependent on both the magnitude of 3TF expression and reprogramming-induced inflammation.