Start Date / Time | November 9, 2016 at 9:00 AM |
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End Date / Time | November 9, 2016 at 9:55 AM |
Duration | 55 minutes |
Location | 512 Light Hall |
Presenter Name | Hannah Worchel (Magnuson lab) |
Presentation Title | Pancreatic Inflammation Redirects Acinar to Beta Cell Reprogramming |
Status | This meeting has already occurred |
Adenoviral delivery of Pdx1, Neurog3 and MafA (3TF) to the pancreas of mice has been shown to reprogram pancreatic acinar cells into insulin-expressing beta-like cells. However, for pancreatic cellular reprogramming to ever become a viable human therapy, a greater understanding of the factors that both promote and limit reprogramming as well as the affects that acinar to beta-cell conversion has on pancreas histology and physiology is required. Using a novel mouse model that expresses 3TF in both a pancreatic acinar cell- and doxycycline-dependent manner, we discovered that the outcome of transcription factor-mediated acinar to beta-cell reprogramming is highly dependent on both the magnitude of 3TF expression and reprogramming-induced inflammation.