Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: Beta cell Islet

Record History
Added on September 7, 2016 at 4:37 PM by Brown, Deborah
Modified on September 28, 2016 at 9:28 AM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Master

Meeting Details

Start Date / Time October 12, 2016 at 9:00 AM
End Date / Time October 12, 2016 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Emily M. Walker, PhD (Stein lab)
Presentation Title Examples of how MafA and MafB can influence human β cells
Status This meeting has already occurred

Meeting Agenda/Notes

MafA is produced at the onset of rodent insulin+ cell formation during development and exclusively in adult islet β cells. Closely related MafB precedes MafA production during development, but is not expressed in murine islet β cells postnatally except for a subset during pregnancy. However, human MafB appears to be coexpressed with MafA in islet β cells. I have developed a transgenic mouse model that specifically mis-expresses MafB in islet β cells, and will discuss its impact on these adult cells normally and in response to pregnancy. In addition, I will describe the biochemical properties of a novel human MafA mutation associated with a condition called insulinomatosis, in which affected individuals develop type 2 like diabetes in their 20s or pancreatic hyperinsulinemia/hypoglycemia from insulinomas in their 50s.