|Start Date / Time||October 12, 2016 at 9:00 AM|
|End Date / Time||October 12, 2016 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Emily M. Walker, PhD (Stein lab)|
|Presentation Title||Examples of how MafA and MafB can influence human β cells|
|Status||This meeting has already occurred|
MafA is produced at the onset of rodent insulin+ cell formation during development and exclusively in adult islet β cells. Closely related MafB precedes MafA production during development, but is not expressed in murine islet β cells postnatally except for a subset during pregnancy. However, human MafB appears to be coexpressed with MafA in islet β cells. I have developed a transgenic mouse model that specifically mis-expresses MafB in islet β cells, and will discuss its impact on these adult cells normally and in response to pregnancy. In addition, I will describe the biochemical properties of a novel human MafA mutation associated with a condition called insulinomatosis, in which affected individuals develop type 2 like diabetes in their 20s or pancreatic hyperinsulinemia/hypoglycemia from insulinomas in their 50s.