|Start Date / Time||September 14, 2016 at 9:00 AM|
|End Date / Time||September 14, 2016 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Jennifer S. Stancill (Magnuson lab)|
|Presentation Title||An RNASeq-based approach to understanding β-cell response to metabolic stress|
|Status||This meeting has already occurred|
In Type 2 Diabetes, multiple metabolic and genetic factors coincide to impair β-cell function. Stresses include increased glycolytic flux due to hyperglycemia (glucotoxicity), excessive intracellular fatty acids due to obesity (lipotoxicity), and an elevated intracellular Ca2+ concentration (excitotoxicity). These stresses, if left uncorrected, cause oxidative and ER stress, and ultimately result in cellular dysfunction, loss of β-cell identity, and death. I will discuss our progress towards understanding how individual stresses contribute to β-cell failure, and how we will use network biology to identify modules of affected genes and their upstream regulators.