Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cells Islet

Record History
Added on September 7, 2016 at 4:34 PM by Brown, Deborah
Modified on September 7, 2016 at 4:34 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Master

Meeting Details

Start Date / Time September 14, 2016 at 9:00 AM
End Date / Time September 14, 2016 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Jennifer S. Stancill (Magnuson lab)
Presentation Title An RNASeq-based approach to understanding β-cell response to metabolic stress
Status This meeting has already occurred

Meeting Agenda/Notes

In Type 2 Diabetes, multiple metabolic and genetic factors coincide to impair β-cell function. Stresses include increased glycolytic flux due to hyperglycemia (glucotoxicity), excessive intracellular fatty acids due to obesity (lipotoxicity), and an elevated intracellular Ca2+ concentration (excitotoxicity). These stresses, if left uncorrected, cause oxidative and ER stress, and ultimately result in cellular dysfunction, loss of β-cell identity, and death. I will discuss our progress towards understanding how individual stresses contribute to β-cell failure, and how we will use network biology to identify modules of affected genes and their upstream regulators.