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SPRING Meeting

Vivian Gama, Ph.D.
Assistant Professor of Cell and Developmental Biology

Record History
Added on January 5, 2016 at 12:20 PM by Uttz, Pam
Modified on April 1, 2016 at 2:27 PM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time April 6, 2016 at 9:00 AM
End Date / Time April 6, 2016 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name Vivian Gama, Ph.D.
Presentation Title Mcl-1 as a molecular modulator of stem cell fate
Status This meeting has already occurred

Meeting Agenda/Notes

Mcl-1 is an anti-apoptotic protein that promotes the survival of different cell lineages and it is frequently upregulated in several types of cancer. Mcl-1 anti-apoptotic function relies on its ability to inhibit Bax activation, the main mediator of cell death in mammalian cells. While investigating the role of Mcl-1 in inhibiting active Bax in human embryonic stem (hES) cells, we found that Mcl-1 has an unexpected role regulating pluripotency in these cells. Using genetic and biochemical approaches we are seeking to reveal the mechanism by which Mcl-1 exerts this non-apoptotic function as a mediator of pluripotency in hES cells.