|Start Date / Time||March 23, 2016 at 9:00 AM|
|End Date / Time||March 23, 2016 at 10:00 AM|
|Location||9455 MRB IV|
|Presenter Name||Sarah Short, Ph.D.|
|Presentation Title||MTGR1 regulates stem cell function and differentiation in the intestine|
|Status||This meeting has already occurred|
The Myeloid Translocation Gene (MTG) family are transcriptional co-repressors known to regulate stem cell function and differentiation in hematopoiesis, however little is currently known about these proteins in other tissue types. We have observed one MTG family member, MTGR1, regulates stem cell and secretory cell populations in the intestine by interfering with both Wnt and Notch signal activation. Using a variety of in vivo and ex vivo models, our current research is focused on the functional impact of MTGR1 in stem cell regulation as it pertains to intestinal injury and disease.