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Keywords: BIG beta cell

Record History
Added on December 4, 2015 at 8:33 AM by Brown, Deborah
Modified on March 11, 2016 at 10:26 AM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Master

Meeting Details

Start Date / Time April 27, 2016 at 9:00 AM
End Date / Time April 27, 2016 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Danielle Dean (Al Powers' lab)
Presentation Title Interruption of Glucagon Signaling Stimulates Alpha Cell Proliferation: Evidence of Hepatic-Islet Alpha Cell Axis
Status This meeting has already occurred

Meeting Agenda/Notes

Interventions decreasing glucagon action may be a useful therapeutic approach for diabetes. However, interruption of glucagon action in mice by several approaches [glucagon receptor global or liver specific knockout, antibodies, or antagonists] leads to hyperglucagonemia and alpha cell hyperplasia. We investigated the mechanism leading to alpha cell hyperplasia and found using islet transplantation models that a signal in mice with interrupted glucagon action stimulated alpha cell proliferation in both donor human and mouse islets independent of the pancreatic environment. This suggested a circulating hepatic factor is responsible. We developed an alpha cell proliferation assay where serum from mice with interrupted glucagon signaling stimulated alpha cell proliferation. Using a combination of liver transcriptomics and serum fractionation/proteomics/metabolomics, we identified a factor in blood that selectively stimulates alpha cell proliferation