Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.be

Keywords: BIG beta cell

Record History
Added on December 4, 2015 at 8:33 AM by Brown, Deborah
Modified on March 11, 2016 at 10:26 AM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Master

Meeting Details

Start Date / Time April 27, 2016 at 9:00 AM
End Date / Time April 27, 2016 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Danielle Dean (Al Powers' lab)
Presentation Title Interruption of Glucagon Signaling Stimulates Alpha Cell Proliferation: Evidence of Hepatic-Islet Alpha Cell Axis
Status This meeting has already occurred

Meeting Agenda/Notes

Interventions decreasing glucagon action may be a useful therapeutic approach for diabetes. However, interruption of glucagon action in mice by several approaches [glucagon receptor global or liver specific knockout, antibodies, or antagonists] leads to hyperglucagonemia and alpha cell hyperplasia. We investigated the mechanism leading to alpha cell hyperplasia and found using islet transplantation models that a signal in mice with interrupted glucagon action stimulated alpha cell proliferation in both donor human and mouse islets independent of the pancreatic environment. This suggested a circulating hepatic factor is responsible. We developed an alpha cell proliferation assay where serum from mice with interrupted glucagon signaling stimulated alpha cell proliferation. Using a combination of liver transcriptomics and serum fractionation/proteomics/metabolomics, we identified a factor in blood that selectively stimulates alpha cell proliferation