|Start Date / Time||April 13, 2016 at 9:00 AM|
|End Date / Time||April 13, 2016 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Bethany Carboneau (Maureen Gannon's lab|
|Presentation Title||“Regulation of β-Cell Mass Expansion by Prostaglandin E2 Signaling”|
|Status||This meeting has already occurred|
Prostaglandins are important modulators of an array of physiologic functions including insulin secretion and systemic inflammation. EP3 and EP4 play opposing roles in many cell types due to signaling through different G proteins, resulting in Gi inhibition (EP3) or Gs stimulation (EP4) of adenylyl cyclase. We hypothesize that EP3 and EP4 play opposing roles in regulating β-cell mass expansion. Signaling via EP3 is predicted to inhibit β-cell proliferation whereas activation of EP4 is predicted to enhance β-cell proliferation and survival. I will discuss my studies using genetic and pharmacological tools to examine the effects of EP3 and EP4 signaling in β-cell proliferation and survival in vivo and in ex vivo studies using rodent and human islets.