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|Start Date / Time||February 17, 2016 at 9:00 AM|
|End Date / Time||February 17, 2016 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Peter Kropp (Maureen Gannon's lab)|
|Presentation Title||Cooperative activity of Pdx1 and Oc1 within the pancreatic progenitors establishes competency for beta cell function|
|Status||This meeting has already occurred|
We have discovered a dosage-dependent and cooperative role of Pdx1 and Oc1 in specification of the endocrine lineage. Heterozygosity for both Pdx1 and Oc1 results in a reduction in the number of hormone-positive cells during development and subsequent impairment in beta-cell function postnatally.