|Start Date / Time||February 3, 2016 at 9:00 AM|
|End Date / Time||February 3, 2016 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Leslie Roteta (Kasey Vickers' lab)|
|Presentation Title||“Islet-originating miR-375 is exported to HDL and dysregulated in T2D"|
|Status||This meeting has already occurred|
Summary: microRNAs (miRNAs) are powerful regulators of glucose metabolism and contribute to the pathogenesis of type 2 diabetes (T2D). Recently, we reported that high-density lipoproteins (HDL) transport and deliver functional miRNAs to recipient cells. We have profiled HDL from both healthy and T2D subjects and found that miR-375 levels are reduced in T2D subjects, as well as in a rodent model of T2D, the ZDF rat. miR-375 is predominantly expressed in the islet where it regulates cell development, prolifereation and insulin secretion. Furthermore, we have found that miR-375, is exported from beta cells in vitro to HDL and this export is altered by glucose concentrations. Collectively, we proposed that HDL-miR-375 forms part of a novel endocrine-like pathway and our in vitro and in vivo studies aim to understand the mechanism by which miR-375 is exported from beta cells to HDL and the physiological changes that occur when this pathway is disturbed.