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Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.


Record History
Added on October 22, 2015 at 2:59 PM by Brown, Deborah
Modified on January 13, 2016 at 12:44 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Master

Meeting Details

Start Date / Time January 20, 2016 at 9:00 AM
End Date / Time January 20, 2016 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Leslie Roteta (Kasey Vickers' lab)
Presentation Title Islet-originating miR-375 is exported to HDL and dysregulated in T2D
Status This meeting has already occurred

Meeting Agenda/Notes

Summary: microRNAs (miRNAs) are powerful regulators of glucose metabolism and contribute to the pathogenesis of type 2 diabetes (T2D). Recently, we reported that high-density lipoproteins (HDL) transport and deliver functional miRNAs to recipient cells. We have profiled HDL from both healthy and T2D subjects and found that miR-375 levels are reduced in T2D subjects, as well as in a rodent model of T2D, the ZDF rat. miR-375 is predominantly expressed in the islet where it regulates cell development, prolifereation and insulin secretion. Furthermore, we have found that miR-375, is exported from beta cells in vitro to HDL and this export is altered by glucose concentrations. Collectively, we proposed that HDL-miR-375 forms part of a novel endocrine-like pathway and our in vitro and in vivo studies aim to understand the mechanism by which miR-375 is exported from beta cells to HDL and the physiological changes that occur when this pathway is disturbed.