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|Start Date / Time||October 28, 2015 at 9:00 AM|
|End Date / Time||October 28, 2015 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Nicholas C. Vierra|
|Presentation Title||“Novel insights into the modulation of islet hormone secretion and metabolic homeostasis by the two-pore domain K+ channel TALK-1"|
|Status||This meeting has already occurred|
The two-pore domain K+ channel TALK-1 is the most abundant K+ channel in the pancreatic islet, where it regulates β-cell excitability and insulin secretion. Interestingly, mice lacking TALK-1 channels are protected from diet-induced hyperglycemia and obesity. This presentation will focus on the function of TALK-1 channels in other endocrine cell types, and possible mechanisms by which TALK-1 channels participate in the pathogenesis of hyperglycemia and obesity.