|Start Date / Time||October 19, 2015 at 12:15 PM|
|End Date / Time||October 19, 2015 at 1:15 PM|
|Location||1220 MRB III|
|Presenter Name||Ken Zaret, Ph.D.|
|Presentation Title||"Overcoming Impediments to Cellular Reprogramming"|
|Status||This meeting has already occurred|
Cell fate changes in embryonic development, tissue regeneration, and cellular reprogramming require that silent genes in closed chromatin can be assessed by transcription factors. We found that fate-changing transcription factors often have the inherent biochemical property of being able to bind nucleosomal DNA, when other factors cannot, correlating with their ability to engage closed chromatin in vitro and in vivo. Yet higher-order heterochromatic structures block many transcription factors from accessing nucleosomal DNA and thereby impede cellular reprogramming. My talk will focus on the balance between reprogramming factors and repressive chromatin states, in order to enhance cell programming.