Ken Zaret, Ph.D.
Joseph Leidy Professor of Cell and Developmental Biology
University of Pennsylvania, Perelman School of Medicine


Record History
Added on September 15, 2015 at 1:14 PM by Uttz, Pam
Modified on September 15, 2015 at 1:14 PM by Uttz, Pam
Shared with (contributions)
Public: VCSCB/CDB Seminar Series

Meeting Details

Start Date / Time October 19, 2015 at 12:15 PM
End Date / Time October 19, 2015 at 1:15 PM
Duration 1 hour(s)
Location 1220 MRB III
Presenter Name Ken Zaret, Ph.D.
Presentation Title "Overcoming Impediments to Cellular Reprogramming"
Status This meeting has already occurred

Meeting Agenda/Notes

Cell fate changes in embryonic development, tissue regeneration, and cellular reprogramming require that silent genes in closed chromatin can be assessed by transcription factors. We found that fate-changing transcription factors often have the inherent biochemical property of being able to bind nucleosomal DNA, when other factors cannot, correlating with their ability to engage closed chromatin in vitro and in vivo. Yet higher-order heterochromatic structures block many transcription factors from accessing nucleosomal DNA and thereby impede cellular reprogramming. My talk will focus on the balance between reprogramming factors and repressive chromatin states, in order to enhance cell programming.