Adrian Cadar
Graduate Student
Hong Lab


Record History
Added on September 15, 2015 at 1:06 PM by Uttz, Pam
Modified on November 16, 2015 at 2:28 PM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time November 18, 2015 at 9:00 AM
End Date / Time November 18, 2015 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name Adrian Cadar
Presentation Title Real-time visualization of endogenous titin dynamics in human induced pluripotent stem cell-derived cardiomyocytes
Status This meeting has already occurred

Meeting Agenda/Notes

The giant myofilament protein titin is a critical determinant of myofibril elasticity and sarcomere structure in striated muscle. Although significant advances have been made in our understanding of the biophysical and mechanical properties of titin, the mechanisms governing titin turnover are poorly understood. I will present work regarding the generation of a novel hiSPC line via CRISPR/Cas9 gene editing that allows for the direct visualization of endogenous titin incorporation and turnover in the sarcomeric complex in beating human cardiomyocytes.