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Insulin Clamp
- Peripheral infusion of 3-3H-Glucose and Insulin
- Peripheral infusion of Glucose to maintain desired
concentration
- Blood sampled via arterial catheter
- 14C-2-Deoxyglucose optional (measure muscle glucose
uptake)
Pancreatic Clamp
- Peripheral infusion of 3-3H-Glucose and somatostation (inhibit
endogenous production of insulin & glucagon
- Intraportal infusion of insulin and glucagon at set
concentrations
- Peripheral infusion of glucose to maintain desired
concentration
- Blood sampled via arterial &/or portal vein catheter
- 14C optional
Hyperglycemic Clamp
- Peripheral infusion of glucose to maintain desired
concentration, typicall 200 mg/dl measured by glucometer
- Blood sampled via arterial catheter
Tolerance Test
- Glucose or Insulin
- Oral, Intravenous, or Intraperitoneal
- Blood sampled via arterial catheter
Pharmacokinetic Study (PK)
- Administration of substrate(s) by single infusion or bolus via
venous catheter, oral gavage, IP injection, or SC injection
- Blood sampled from arterial catheter
Blood Pressure Measurement
- Requires access to cannulated artery, typically carotid
artery
- Arterial catheter conneced to an external pressure
transducer
- Data recorded using BioPac software
Dosing
Techniques
- Oral Gavage
- Subcutaneous injection
- Intraperitoneal injection
- Intravenous injection (catheter or tail vein)
Sampling Techniques
- Tail vein under anesthesia
- Tail clip
- Surgical catheters
- Cardiac puncture
- Cisterna magna under anesthesia