Rat Metabolic Physiology Core (RMPC) 

Record History
Added on July 23, 2015 at 10:16 AM by Lindner, Jill
Modified on January 9, 2019 at 11:35 AM by Farmer, Tiffany
Shared with (contributions)
Public: Shared Collection
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The Metabolic Physiology Shared Resource (MPSR) (Kevin Niswender, MD, Ph.D., Director) assists investigators wishing to address hypotheses related to diabetes and metabolism. The Rat Metabolic Physiology Core (RMPC) is a section of the MPSR that provides novel techniques to better understand specifically rat models of diabetes and its complications. We are located in rooms 7440 MRBIV (lab) and 7435 MRBIV (office).

The RMPC offers a variety of services including:

  • Chronic artery &/or vein cannulation
  • Ileal vein cannulation
  • Portal vein cannulation
  • Insulin clamp
  • Pancreatic clamp
  • Hyperglycemic Clamp
  • Drug Metabolism and Pharmacokinetic Study
  • Indirect calorimetry
  • Blood pressure measurement
  • and more


Surgical procedures

Non-Surgical Procedures 

Indirect Calorimetry



Contact Info:

Director:   Kevin Niswender, MD, PhD    kevin.niswender@vanderbilt.edu

Lab Manager:  Tiffany Farmer, MS    t.farmer@vumc.org


Our Goals

  • broaden the scope of techniques available to investigators
  • standardize key methodologies
  • expedite the completion of research


    The Rat Metabolic Physiology Sub-Core is supported by NIH grant DK020593.  Please acknowledge this in your publications.


Resource  Type Keywords ID
Rat Metabolic Physiology Sub-Core Contact UsPage13192
Rat Metabolic Physiology Sub-Core PricingPageservice fees, pricing13193
Rat Metabolic Physiology Sub-Core ServicesCollectionCalorimetry, Procedures, Surgery13892
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Publications / Citations

  1. Comparison of the physiological relevance of systemic vs. portal insulin delivery to evaluate whole body glucose flux during an insulin clamp. Farmer TD, Jenkins EC, O'Brien TP, McCoy GA, Havlik AE, Nass ER, Nicholson WE, Printz RL, Shiota M (2015) Am J Physiol Endocrinol Metab 308(3): E206-22
    › Primary publication · 25516552 (PubMed) · PMC4312835 (PubMed Central) · Added on 2/19/2015

MeSH Terms

Administration, Intravenous Animals Blood Glucose Catheterization, Peripheral Glucagon Glucose Clamp Technique Hyperglycemia Insulin Male Portal Vein Rats Rats, Sprague-Dawley