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Keywords: beta cell BIG

Record History
Added on January 9, 2015 at 2:15 PM by Brown, Deborah
Modified on July 17, 2015 at 1:30 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time July 22, 2015 at 9:00 AM
End Date / Time July 22, 2015 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Hannah Worchel (Magnuson's lab)
Presentation Title Inflammation Diverts Transcription Factor-mediated Acinar to Beta Cell Reprogramming to an Alternate Cell Fate
Status This meeting has already occurred

Meeting Agenda/Notes

Adenoviral delivery of Pdx1/Ngn3/MafA (3TF) to the pancreas of immunocompromised, Rag1-/- mice reprograms pancreatic acinar cells into insulin-expressing beta-like cells. However,we have found that tetracycline-induced acinar-specific expression of 3TF transgene in Rag1+/+ mice does not result in the production of new insulin-secreting cells. Instead, 7 days of 3TF transgene expression results in the conversion of acinar cells into progenitor, duct-like cells and is associated with a potent inflammatory response with the pancreata exhibiting hallmarks of acinar-to-ductal metaplasia (ADM). We have found that when macrophages are depleted prior to and during inducing 3TF expression, the ADM-like phenotype does not occur, and acinar-derived beta-cells are generated.