|Start Date / Time||July 8, 2015 at 9:00 AM|
|End Date / Time||July 8, 2015 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Lisette Maddison, PhD (Wenbiao Chen's lab)|
|Presentation Title||Death and the β-cell: convergence of multiple pathways leading to β-cell loss in a model of peripheral insulin resistance|
|Status||This meeting has already occurred|
Prolonged insulin resistance can lead to β-cell dysfunction and eventually loss of β-cells. It is important to understand the mechanisms that lead to β-cell loss under these conditions to improve β-cell survival. We have developed a zebrafish model of skeletal muscle insulin resistance that in conjunction with overnutrition exhibits a rapid loss of β-cells. I will present evidence that ER stress, inflammation, necroptosis and macrophage infiltration are all involved in the elimination of β-cells in this model.