Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.


Keywords: beta cell BIG

Record History
Added on January 9, 2015 at 2:09 PM by Brown, Deborah
Modified on June 25, 2015 at 10:20 AM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time July 8, 2015 at 9:00 AM
End Date / Time July 8, 2015 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Lisette Maddison, PhD (Wenbiao Chen's lab)
Presentation Title Death and the β-cell: convergence of multiple pathways leading to β-cell loss in a model of peripheral insulin resistance
Status This meeting has already occurred

Meeting Agenda/Notes

Prolonged insulin resistance can lead to β-cell dysfunction and eventually loss of β-cells.  It is important to understand the mechanisms that lead to β-cell loss under these conditions to improve β-cell survival.   We have developed a zebrafish model of skeletal muscle insulin resistance that in conjunction with overnutrition exhibits a rapid loss of β-cells.  I will present evidence that ER stress, inflammation, necroptosis and macrophage infiltration are all involved in the elimination of β-cells in this model.