Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on January 8, 2015 at 2:55 PM by Brown, Deborah
Modified on May 7, 2015 at 8:12 AM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (IBIG) Seminar Master

Meeting Details

Start Date / Time May 13, 2015 at 9:00 AM
End Date / Time May 13, 2015 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Jennifer Stancill (Magnuson's lab)
Presentation Title Aberrant Ca2+-signaling disrupts islet morphology and affects β-cell identity
Status This meeting has already occurred

Meeting Agenda/Notes

It remains unclear how voltage-dependent and non-dependent signaling pathways in pancreatic β-cells contribute to their failure in Type 2 diabetes (T2D), and why mice lacking either Abcc8 or Kcnj11, components of the ATP-sensitive potassium channel, exhibit progressive changes in islet morphology. I will discuss our findings about how lack of Abcc8 affects islet morphology and cell identity as well as our progress toward profiling gene expression changes in β-cells with chronically elevated [Ca2+]i and how these gene expression changes may contribute to β-cell failure.