|Start Date / Time||May 13, 2015 at 9:00 AM|
|End Date / Time||May 13, 2015 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Jennifer Stancill (Magnuson's lab)|
|Presentation Title||Aberrant Ca2+-signaling disrupts islet morphology and affects β-cell identity|
|Status||This meeting has already occurred|
It remains unclear how voltage-dependent and non-dependent signaling pathways in pancreatic β-cells contribute to their failure in Type 2 diabetes (T2D), and why mice lacking either Abcc8 or Kcnj11, components of the ATP-sensitive potassium channel, exhibit progressive changes in islet morphology. I will discuss our findings about how lack of Abcc8 affects islet morphology and cell identity as well as our progress toward profiling gene expression changes in β-cells with chronically elevated [Ca2+]i and how these gene expression changes may contribute to β-cell failure.