Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on January 8, 2015 at 2:51 PM by Brown, Deborah
Modified on April 7, 2015 at 12:21 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time April 15, 2015 at 9:00 AM
End Date / Time April 15, 2015 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Kayla Boortz (O'Brien's lab)
Presentation Title Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells
Status This meeting has already occurred

Meeting Agenda/Notes

G6PC2 and glucokinase together form a substrate cycle that determines the sensitivity of glucose-stimulated insulin secretion to glucose. Genetic and molecular studies have shown that elevated G6PC2 expression increases fasting blood glucose (FBG) but, because this is detrimental to health, it suggests that G6PC2 evolved for another purpose. In this seminar I will present data suggesting that glucocorticoids induce G6pc2 expression in order to to modulate the glucose sensitivity of insulin secretion under conditions of glucocorticoid-induced stress.