Start Date / Time | April 15, 2015 at 9:00 AM |
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End Date / Time | April 15, 2015 at 9:55 AM |
Duration | 55 minutes |
Location | 512 Light Hall |
Presenter Name | Kayla Boortz (O'Brien's lab) |
Presentation Title | Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells |
Status | This meeting has already occurred |
G6PC2 and glucokinase together form a substrate cycle that determines the sensitivity of glucose-stimulated insulin secretion to glucose. Genetic and molecular studies have shown that elevated G6PC2 expression increases fasting blood glucose (FBG) but, because this is detrimental to health, it suggests that G6PC2 evolved for another purpose. In this seminar I will present data suggesting that glucocorticoids induce G6pc2 expression in order to to modulate the glucose sensitivity of insulin secretion under conditions of glucocorticoid-induced stress.