Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on January 8, 2015 at 2:44 PM by Brown, Deborah
Modified on February 26, 2015 at 8:39 AM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time March 4, 2015 at 9:00 AM
End Date / Time March 4, 2015 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Chen Huang (Gu's lab)
Presentation Title Loss of Myt factors compromises postnatal beta-cell differentiation and survival
Status This meeting has already occurred

Meeting Agenda/Notes

In vitro generation of beta cell has become an ideal source for transplantation-based therapy against diabetes. However, long-term challenge remains in obtaining fully functional and long-lived beta cells, necessitating a comprehensive understanding of postnatal beta cell regulation. Here we show that myelin transcription (MYT) factors are a group of genes that are required to generate and maintain mature beta cells. Pancreatic knockout of Myt factors mice exhibit overt diabetes around 1 month of age, accompanied with hugely loss of beta cell mass and compromised insulin secretion. Detailed examination found that loss of beta cell mass was caused by insufficient cell proliferation and increased cell apoptosis. Moreover, expression of a set of genes required for beta cell function is compromised in Myt mutant mice.  Finally, we found Myt mutant beta cells reverse the postnatal differentiation and lose mature beta cell features. Overall, our results unravel a crucial family of genes playing a role of pro-proliferation, pro-differentiation and anti-apoptotic in postnatal beta cells.