Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell; BIG

Record History
Added on November 11, 2014 at 9:25 AM by Brown, Deborah
Modified on November 14, 2014 at 1:23 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time November 19, 2014 at 9:00 AM
End Date / Time November 19, 2014 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Benjamin Glaser, MD, Hadassah-Hebrew Univ Med Ctr
Presentation Title Glycolysis Control of Beta-cell Fate
Status This meeting has already occurred

Meeting Agenda/Notes

Pancreatic beta-cell plasticity, defined as its ability to self-replicate, de-differentiate and trans-differentiate, has recently become the subject of extensive study.  Beta-cell glycolytic flux, and thus demand for insulin secretion (work-load), appears to be the major regulator controlling entry into the cell cycle.  However, increased glycolytic flux also has a toxic effect, modulated by expression of p53, evidence suggesting DNA damage as well as evidence of de-differentiation and even trans-differentiation to other endocrine cell types.  GLP1 agonists may be able to prevent, at least partially, these toxic effects.