Start Date / Time | November 19, 2014 at 9:00 AM |
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End Date / Time | November 19, 2014 at 9:55 AM |
Duration | 55 minutes |
Location | 512 Light Hall |
Presenter Name | Benjamin Glaser, MD, Hadassah-Hebrew Univ Med Ctr |
Presentation Title | Glycolysis Control of Beta-cell Fate |
Status | This meeting has already occurred |
Pancreatic beta-cell plasticity, defined as its ability to self-replicate, de-differentiate and trans-differentiate, has recently become the subject of extensive study. Beta-cell glycolytic flux, and thus demand for insulin secretion (work-load), appears to be the major regulator controlling entry into the cell cycle. However, increased glycolytic flux also has a toxic effect, modulated by expression of p53, evidence suggesting DNA damage as well as evidence of de-differentiation and even trans-differentiation to other endocrine cell types. GLP1 agonists may be able to prevent, at least partially, these toxic effects.