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SPRING meeting

Aaron Bowman, Ph.D.
Assistant Professor
Department of Neurology
Vanderbilt Kennedy Center

Record History
Added on August 22, 2014 at 11:16 AM by Uttz, Pam
Modified on October 29, 2014 at 10:53 AM by Cornwell, Kim
Shared with (contributions)
Public: SPRING meeting

Meeting Details

Start Date / Time November 5, 2014 at 9:00 AM
End Date / Time November 5, 2014 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name Aaron Bowman, Ph.D.
Presentation Title Human stem cell models to examine manganese neurobiology in health and disease
Status This meeting has already occurred

Meeting Agenda/Notes

The essential micronutrient manganese (Mn) is enriched in brain, especially the basal ganglia. This brain region is also highly vulnerable to Mn neurotoxicity. We have used human induced pluripotent stem cell derived neurons to examine alterations in Mn neurobiology that occur in striatal lineage neuroprogenitors in the context of Huntington’s disease as well as neurodevelopmental changes in Mn handling that occur in the mesencephalic dopaminergic neuron lineage.