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|Start Date / Time||April 24, 2013 at 9:00 AM|
|End Date / Time||April 24, 2013 at 10:00 AM|
|Location||512 Light Hall|
|Presenter Name||Neil Phillips (Powers lab)|
|Presentation Title||Development of RNA aptamers for beta cell imaging|
|Status||This meeting has already occurred|
This is currently an unmet need for the in-situ, non-invasive determination of beta cell mass (BCM) in a patient. Current state of the art in terms of imaging BCM (18F-Fallypride PET, 18F-Exendin, conjugated antibodies/ peptides) is limited by low sensitivity, high background and poor specificity. We are developing novel oligonucleotide imaging probes specific for pancreatic human islets and beta cells that can be used to longitudinally follow changes in beta cell mass. Derivization of functional groups on the oligonucleotide sequence allows the addition of imaging agents that can be used in PET, SPECT, MRI and Optical modalities, and therapeutics such as inhibitory RNA, DNA, drugs and toxins, allowing these platforms to be used for dual theranostic use.