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|Start Date / Time||April 10, 2013 at 9:00 AM|
|End Date / Time||April 10, 2013 at 10:00 AM|
|Location||512 Light Hall|
|Presenter Name||Jing Liu (Gu lab)|
|Presentation Title||Stochastic-like Activation of Myt1/Nkx2.2 in Subsets of Ngn3-Expressing Progenitors Facilitates Beta Cell Fate Choice in Pancreatic Development|
|Status||This meeting has already occurred|
Ngn3+ progenitors give rise to all types of endocrine cells during pancreatic development. However, how endocrine cell fate choice is made remains unclear. Here, we use a bipartite Cre cell lineage tracing system to show that coexpression of Myt1/Nkx2.2 with Ngn3 biases Ngn3+ progenitors towards beta cell fate.