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|Start Date / Time||May 1, 2013 at 9:00 AM|
|End Date / Time||May 1, 2013 at 10:00 AM|
|Location||512 Light Hall|
|Presenter Name||Mingyu Li (Chen lab)|
|Presentation Title||Title: Molecular mechanisms of overnutrition-induced β cell neogenesis in zebrafish|
|Status||This meeting has already occurred|
Overnutrition induces rapid β cell differentiation in larval zebrafish but how overnutrition is sensed and what factor(s) mediates the differentiation remain unknown. I will present data showing that persistent activation of β cell secretion and FGF1 are necessary for overnutrition-induced β cell differentiation. I will discuss a potential mechanism that links FGF1 secretion to persistent β cell activation.