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Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.


Record History
Added on October 4, 2012 at 3:11 PM by Brown, Deborah
Modified on April 11, 2013 at 8:34 AM by Brown, Deborah
Shared with (contributions)
Public: Beta Cell Interest Group (BIG) Weekly Seminar
BIG: Beta Cell Interest Group (BIG) Weekly Seminar Master

Meeting Details

Start Date / Time April 17, 2013 at 9:00 AM
End Date / Time April 17, 2013 at 10:00 AM
Duration 1 hour(s)
Location 512 Light Hall
Presenter Name Fong Cheng Pan (Wright lab)
Presentation Title Mnx1 as a critical determinant in b/d fate selection during endocrine lineage diversification
Status This meeting has already occurred

Meeting Agenda/Notes

Mnx1 (HB9, Hlxb9) is expressed in early multipotent pancreatic progenitors, and later restricted to the mature b cells. Mnx1 global null mice have dorsal pancreas agenesis, while ventral pancreas develops normally significantly reduced numbers of b cells that are immature. However, its function in b cells have not been examined so far. Here, I will present data on novel roles of Mnx1 in b/d cell fate selection during endocrine differentiation, and its function in b cell fate maintenance and proliferation.