Keyword Connections

•  Danielle Dean
•  Daniel Moore

•  Peggy Kendall
•  Rachel Bonami

•  Subhadra Gunawardana

Resources

• 2013 P&F Recipients: Project Summaries

Communities

• James (Tom) Thomas Laboratory
• Kendall Laboratory
• Vanderbilt Diabetes Research and Training Center

Publications

• Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial.
  Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Krischer JP, Skyler JS, Type 1 Diabetes TrialNet Abatacept Study Group
  (2011) Lancet 378: 412-9
• Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.
  Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL
  (2014) Nature 514: 503-7
• A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus.
  Concannon P, Gogolin-Ewens KJ, Hinds DA, Wapelhorst B, Morrison VA, Stirling B, Mitra M, Farmer J, Williams SR, Cox NJ, Bell GI, Risch N, Spielman RS
  (1998) Nat Genet 19: 292-6
• An encapsulation system for the immunoisolation of pancreatic islets.
  Wang T, Lacík I, Brissová M, Anilkumar AV, Prokop A, Hunkeler D, Green R, Shahrokhi K, Powers AC
  (1997) Nat Biotechnol 15: 358-62
• Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.
  Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K
  (2016) Science 351: 711-4
• Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
  Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH
  (2006) Science 311: 1774-5
• Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.
  Westermark P, Andersson A, Westermark GT
  (2011) Physiol Rev 91: 795-826
• Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice.
  Greeley SA, Katsumata M, Yu L, Eisenbarth GS, Moore DJ, Goodarzi H, Barker CF, Naji A, Noorchashm H
  (2002) Nat Med 8: 399-402
• Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
  Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC
  (2016) Nat Med 22: 1482-1487
• The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice.
  Hong S, Wilson MT, Serizawa I, Wu L, Singh N, Naidenko OV, Miura T, Haba T, Scherer DC, Wei J, Kronenberg M, Koezuka Y, Van Kaer L
  (2001) Nat Med 7: 1052-6
• Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.
  Huang X, Moore DJ, Ketchum RJ, Nunemaker CS, Kovatchev B, McCall AL, Brayman KL
  (2008) Endocr Rev 29: 603-30
• Association between cardiovascular autonomic neuropathy and left ventricular dysfunction: DCCT/EDIC study (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications).
  Pop-Busui R, Cleary PA, Braffett BH, Martin CL, Herman WH, Low PA, Lima JAC, Bluemke DA, DCCT/EDIC Research Group
  (2013) J Am Coll Cardiol 61: 447-454
• Association of numeracy and diabetes control.
  Cavanaugh K, Huizinga MM, Wallston KA, Gebretsadik T, Shintani A, Davis D, Gregory RP, Fuchs L, Malone R, Cherrington A, Pignone M, DeWalt DA, Elasy TA, Rothman RL
  (2008) Ann Intern Med 148: 737-46
• Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.
  Wan X, Thomas JW, Unanue ER
  (2016) J Exp Med 213: 967-78
• Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs.
  Rivera N, Ramnanan CJ, An Z, Farmer T, Smith M, Farmer B, Irimia JM, Snead W, Lautz M, Roach PJ, Cherrington AD
  (2010) J Clin Invest 120: 4425-35
• Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.
  Unger RH, Cherrington AD
  (2012) J Clin Invest 122: 4-12
• Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis.
  Winnick JJ, Kraft G, Gregory JM, Edgerton DS, Williams P, Hajizadeh IA, Kamal MZ, Smith M, Farmer B, Scott M, Neal D, Donahue EP, Allen E, Cherrington AD
  (2016) J Clin Invest 126: 2236-48
• Comeback kids: CD8(+) suppressor T cells are back in the game.
  Van Kaer L
  (2010) J Clin Invest 120: 3432-4
• Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.
  Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS, Todd JA, Concannon P
  (2001) Am J Hum Genet 69: 820-30
• Insulin-gene sharing in sib pairs with insulin-dependent diabetes mellitus: no evidence for linkage.
  Cox NJ, Baker L, Spielman RS
  (1988) Am J Hum Genet 42: 167-72
• Spoiling the whole bunch: quality control aimed at preserving the integrity of high-throughput genotyping.
  Pluzhnikov A, Below JE, Konkashbaev A, Tikhomirov A, Kistner-Griffin E, Roe CA, Nicolae DL, Cox NJ
  (2010) Am J Hum Genet 87: 123-8
• Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.
  Ferreira MA, Mangino M, Brumme CJ, Zhao ZZ, Medland SE, Wright MJ, Nyholt DR, Gordon S, Campbell M, McEvoy BP, Henders A, Evans DM, Lanchbury JS, Pereyra F, International HIV Controllers Study, Walker BD, Haas DW, Soranzo N, Spector TD, de Bakker PI, Frazer IH, Montgomery GW, Martin NG
  (2010) Am J Hum Genet 86: 88-92
• Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants.
  Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM, Mosley JD, Zhao S, Raychaudhuri S, Mallal S, Ye Z, Mayer JG, Brilliant MH, Hebbring SJ, Roden DM, Phillips EJ, Denny JC
  (2017) Sci Transl Med 9:
• Molecular genetic analysis of diabetes in mice.
  Gannon M
  (2001) Trends Genet 17: S23-8
• Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.
  Berchtold LA, Størling ZM, Ortis F, Lage K, Bang-Berthelsen C, Bergholdt R, Hald J, Brorsson CA, Eizirik DL, Pociot F, Brunak S, Størling J
  (2011) Proc Natl Acad Sci U S A 108: E681-8
• Mouse models of diabetic nephropathy.
  Breyer MD, Böttinger E, Brosius FC, Coffman TM, Harris RC, Heilig CW, Sharma K, AMDCC
  (2005) J Am Soc Nephrol 16: 27-45
• Replicative capacity of β-cells and type 1 diabetes.
  Saunders D, Powers AC
  (2016) J Autoimmun 71: 59-68
• Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy.
  Yu L, Su Y, Paueksakon P, Cheng H, Chen X, Wang H, Harris RC, Zent R, Pozzi A
  (2012) Kidney Int 81: 1086-97
• Thiazolidinedione use is associated with better survival in hemodialysis patients with non-insulin dependent diabetes.
  Brunelli SM, Thadhani R, Ikizler TA, Feldman HI
  (2009) Kidney Int 75: 961-8
• Effects of sulfonylureas, alpha-endosulfine counterparts, on glomerulosclerosis in type 1 and type 2 models of diabetes.
  Biederman JI, Vera E, Rankhaniya R, Hassett C, Giannico G, Yee J, Cortes P
  (2005) Kidney Int 67: 554-65
• Reversal of type 1 diabetes in mice by brown adipose tissue transplant.
  Gunawardana SC, Piston DW
  (2012) Diabetes 61: 674-82
• Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice.
  Oeser JK, Parekh VV, Wang Y, Jegadeesh NK, Sarkar SA, Wong R, Lee CE, Pound LD, Hutton JC, Van Kaer L, O'Brien RM
  (2011) Diabetes 60: 2922-7
• Revascularization of transplanted islets: can it be improved?
  Brissova M, Powers AC
  (2008) Diabetes 57: 2269-71
• Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants.
  Sosenko JM, Skyler JS, Beam CA, Krischer JP, Greenbaum CJ, Mahon J, Rafkin LE, Matheson D, Herold KC, Palmer JP, Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups
  (2013) Diabetes 62: 4179-83
• Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice.
  Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CV, Hoshino M, Chiba T, Uemoto S
  (2008) Diabetes 57: 2421-31
• Glucagon as a critical factor in the pathology of diabetes.
  Edgerton DS, Cherrington AD
  (2011) Diabetes 60: 377-80
• Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo.
  Wang Y, Flemming BP, Martin CC, Allen SR, Walters J, Oeser JK, Hutton JC, O'Brien RM
  (2008) Diabetes 57: 133-41
• New Players in the Field of T1D: Anti-Peripherin B Lymphocytes.
  Kendall PL
  (2016) Diabetes 65: 1794-6
• A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.
  Paterson AD, Waggott D, Boright AP, Hosseini SM, Shen E, Sylvestre MP, Wong I, Bharaj B, Cleary PA, Lachin JM, MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium), Below JE, Nicolae D, Cox NJ, Canty AJ, Sun L, Bull SB, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
  (2010) Diabetes 59: 539-49
• Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes.
  Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Allen EJ, Donahue EP, Rivera N, Winnick JJ, Edgerton DS, Nishimura E, Fledelius C, Brand CL, Cherrington AD
  (2015) Diabetes 64: 3439-51