Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase.

Gelderman MP, Stuart R, Vigerust D, Fuhrmann S, Lefkowitz DL, Allen RC, Lefkowitz SS, Graham S
Mediators Inflamm. 1998 7 (6): 381-9

PMID: 9927230 · PMCID: PMC1781873 · DOI:10.1080/09629359890758

Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (Mphi) which could explain the perpetuation of inflammation associated with RA. A monoarticular arthritis was induced in female Lewis rats by injection of streptococcal cell wall extracts (PG-APS). After swelling and erythema subsided, joints were re-injected with one of the following: porcine MPO or partially inactivated MPO (iMPO). Injection with either MPO or iMPO induced a 'flare' of experimental RA. Blocking the Mphi-mannose receptor by mannans, ablated exacerbation of disease. These results indicate that MPO or iMPO can play a pivotal role in the perpetuation but not initiation of this RA model.

MeSH Terms (10)

Animals Arthritis, Rheumatoid Disease Models, Animal Female Macrophage Activation Macrophages Neutrophils Peroxidase Rats Rats, Inbred Lew

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