Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis.

Nørgaard P, Law B, Joseph H, Page DL, Shyr Y, Mays D, Pietenpol JA, Kohl NE, Oliff A, Coffey RJ, Poulsen HS, Moses HL
Clin Cancer Res. 1999 5 (1): 35-42

PMID: 9918200

MeSH Terms (16)

Alkyl and Aryl Transferases Animals Apoptosis Calcium-Calmodulin-Dependent Protein Kinases Drug Screening Assays, Antitumor Enzyme Inhibitors Farnesyltranstransferase Female G1 Phase Growth Inhibitors Mammary Neoplasms, Experimental Methionine Mice Mice, Transgenic Receptor, ErbB-2 Transforming Growth Factor alpha

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