Meloxicam inhibits the growth of colorectal cancer cells.

Goldman AP, Williams CS, Sheng H, Lamps LW, Williams VP, Pairet M, Morrow JD, DuBois RN
Carcinogenesis. 1998 19 (12): 2195-9

PMID: 9886578 · DOI:10.1093/carcin/19.12.2195

Cyclooxygenase-2 has been reported to play an important role in colorectal carcinogenesis. The effects of meloxicam (a COX-2 inhibitor) on the growth of two colon cancer cell lines that express COX-2 (HCA-7 and Moser-S) and a COX-2 negative cell line (HCT-116) were evaluated. The growth rate of these cells was measured following treatment with meloxicam. HCA-7 and Moser-S colony size were significantly reduced following treatment with meloxicam; however, there was no significant change in HCT-116 colony size with treatment. In vivo studies were performed to evaluate the effect of meloxicam on the growth of HCA-7 cells when xenografted into nude mice. We observed a 51% reduction in tumor size after 4 weeks of treatment. Analysis of COX-1 and COX-2 protein levels in HCA-7 tumor lysates revealed a slight decrease in COX-2 expression levels in tumors taken from mice treated with meloxicam and no detectable COX-1 expression. Here we report that meloxicam significantly inhibited HCA-7 colony and tumor growth but had no effect on the growth of the COX-2 negative HCT-116 cells.

MeSH Terms (25)

Animals Anti-Inflammatory Agents, Non-Steroidal Cell Division Collagen Colorectal Neoplasms Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Dinoprostone Drug Combinations Humans Isoenzymes Laminin Meloxicam Membrane Proteins Mice Mice, Nude Neoplasm Transplantation Prostaglandin-Endoperoxide Synthases Proteoglycans Thiazines Thiazoles Transplantation, Heterologous Tumor Cells, Cultured

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