5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex.

Abi-Saab WM, Bubser M, Roth RH, Deutch AY
Neuropsychopharmacology. 1999 20 (1): 92-6

PMID: 9885788 · DOI:10.1016/S0893-133X(98)00046-3

Monoamines, including both dopamine and serotonin, synapse onto prefrontal cortical interneurons. Dopamine has been shown to activate these GABAergic interneurons, but there are no direct data on the effects of serotonin on GABA release in the prefrontal cortex. We, therefore, examined the effects of the 5-HT2a/c agonist 1-(2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI) on extracellular GABA levels in the prefrontal cortex of the rat. Local infusions of DOI dose-dependently increased cortical extracellular GABA levels. In addition, systemic DOI administration resulted in Fos protein expression in glutamic acid decarboxylase67-immunoreactive interneurons of the prefrontal cortex. These data indicate that serotonin, operating through a 5-HT2 receptor, acutely activates GABAergic interneurons in the prefrontal cortex. These data further suggest that there may be convergent regulation of interneurons by dopamine and serotonin in the prefrontal cortex.

MeSH Terms (13)

Animals gamma-Aminobutyric Acid Immunohistochemistry Indophenol Interneurons Male Neurons Prefrontal Cortex Rats Rats, Sprague-Dawley Receptors, Serotonin Serotonin Serotonin Receptor Agonists

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