Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity.

Whitehead SS, Firestone CY, Karron RA, Crowe JE, Elkins WR, Collins PL, Murphy BR
J Virol. 1999 73 (2): 871-7

PMID: 9882287 · PMCID: PMC103906 · DOI:10.1128/JVI.73.2.871-877.1999

MeSH Terms (21)

Animals Child, Preschool Chlorocebus aethiops Double-Blind Method HN Protein Humans Infant Mice Mice, Inbred BALB C Mutation, Missense Pan troglodytes Respiratory Syncytial Virus, Human Sequence Analysis, DNA Temperature Tumor Cells, Cultured Vaccines, Attenuated Vero Cells Viral Envelope Proteins Viral Proteins Viral Vaccines Virus Replication

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