Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.

Crowe JE, Firestone CY, Crim R, Beeler JA, Coelingh KL, Barbas CF, Burton DR, Chanock RM, Murphy BR
Virology. 1998 252 (2): 373-5

PMID: 9878616 · DOI:10.1006/viro.1998.9462

A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV). Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies.

Copyright 1998 Academic Press.

MeSH Terms (13)

Amino Acid Substitution Animals Antibodies, Monoclonal Cell Line Epitopes Humans Immunoglobulin Fab Fragments Neutralization Tests Point Mutation Recombinant Proteins Respiratory Syncytial Viruses Tumor Cells, Cultured Viral Fusion Proteins

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