Adhesion formation is reduced after laparoscopic surgery.

Garrard CL, Clements RH, Nanney L, Davidson JM, Richards WO
Surg Endosc. 1999 13 (1): 10-3

PMID: 9869679 · DOI:10.1007/s004649900887

BACKGROUND - Adhesion formation after abdominal operations causes significant morbidity.

METHODS - Adhesion formation in pigs was compared after placement of prosthetic mesh during celiotomy (group 1), laparoscopy with large incision (group 2), and laparoscopy (group 3). After peritoneum was excised, polypropylene mesh was fixed to the abdominal wall, then to the opposite abdominal wall in the preperitoneal space followed by peritoneal closure. Adhesion area, grade, and vascularity were measured.

RESULTS - More adhesions (p < 0.02) covered intraperitoneal mesh (7.57 +/- 1.89 cm2) than covered reperitonealized mesh (2.16 +/- 1.13 cm2), and adhesion grade was significantly greater (p < 0.02). Adhesion areas were significantly greater in groups 1 and 2 than in group 3 (p = 0.001 and 0.03, respectively). Adhesion grade was significantly greater in groups 1 and 2 than in group 3 (p = 0.02 and p = 0.04, respectively). Groups 1 and 2 had more vascular adhesions than group 3 (p < 0.01 and p = 0.02, respectively)

CONCLUSIONS - A foreign body within the peritoneum stimulates more numerous and denser adhesions. Tissue trauma distant from the site of adhesions increases their formation. A major advantage of laparoscopic surgery is decreased adhesion formation.

MeSH Terms (12)

Abdomen Animals Disease Models, Animal Female Laparoscopy Peritoneal Diseases Reference Values Surgical Mesh Survival Rate Swine Tissue Adhesions Treatment Outcome

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