A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure.

Moore KP, Holt SG, Patel RP, Svistunenko DA, Zackert W, Goodier D, Reeder BJ, Clozel M, Anand R, Cooper CE, Morrow JD, Wilson MT, Darley-Usmar V, Roberts LJ
J Biol Chem. 1998 273 (48): 31731-7

PMID: 9822635 · DOI:10.1074/jbc.273.48.31731

MeSH Terms (19)

Animals Bicarbonates Dinoprost Disease Models, Animal Electron Spin Resonance Spectroscopy Glycerol Humans Hydrogen-Ion Concentration Kidney Lipoproteins, LDL Metmyoglobin Myoglobin Oxidation-Reduction Potassium Compounds Rats Renal Insufficiency Rhabdomyolysis Spectrophotometry Vasoconstriction

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