An essential role for ectodomain shedding in mammalian development.

Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA
Science. 1998 282 (5392): 1281-4

PMID: 9812885 · DOI:10.1126/science.282.5392.1281

MeSH Terms (22)

ADAM17 Protein ADAM Proteins Amino Acid Sequence Animals Catalytic Domain Cell Membrane Cells, Cultured Crosses, Genetic Embryonic and Fetal Development L-Selectin Ligands Membrane Proteins Metalloendopeptidases Mice Mice, Inbred C57BL Molecular Sequence Data Mutation Phenotype Protein Processing, Post-Translational Receptors, Tumor Necrosis Factor Transforming Growth Factor alpha Tumor Necrosis Factor-alpha

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