The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development.

Labosky PA, Kaestner KH
Mech Dev. 1998 76 (1-2): 185-90

PMID: 9767163 · DOI:10.1016/s0925-4773(98)00105-1

The embryonic neural crest is a unique group of cells that gives rise to the peripheral nervous system as well as many other cell types. Most of the work describing the behavior and specification of these cells has been done in the avian system, a system amenable to experimental manipulations such as tissue grafting, cell transplantation and lineage tracing. This work has been greatly facilitated by the use of molecular markers of neural crest cells such as HNK-1 and slug, markers that are not yet available for the study of mouse neural crest. Here we demonstrate that Hfh2 (HNF3 forkhead homologue 2), a member of the 'winged helix' or 'forkhead' transcription factor gene family, is expressed in premigratory and migrating neural crest cells in the early mouse embryo and in motorneuron progenitors in the developing spinal cord. Using linkage analysis we have localized the Hfh2 gene to chromosome 4 at 44.91 cM from the centromere.

Copyright 1998 Elsevier Science Ireland Ltd. All Rights Reserved.

MeSH Terms (24)

Animals Binding Sites Chromosome Mapping DNA-Binding Proteins Drosophila Proteins Early Growth Response Protein 2 Forkhead Transcription Factors Gene Expression Regulation, Developmental Homeodomain Proteins In Situ Hybridization LIM-Homeodomain Proteins Mice Mice, Inbred Strains Molecular Sequence Data Motor Neurons Nerve Tissue Proteins Neural Crest Proto-Oncogene Proteins Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases Repressor Proteins Rhombencephalon Spinal Cord Transcription Factors

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