Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes.

Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T
Biochem Pharmacol. 1998 56 (2): 243-51

PMID: 9698079 · DOI:10.1016/s0006-2952(98)00133-6

MeSH Terms (18)

Amino Acid Substitution Aryl Hydrocarbon Hydroxylases Catalysis Cytochrome P-450 CYP2C9 Cytochrome P-450 Enzyme System Diclofenac DNA Flurbiprofen Heterozygote Humans Hydroxylation Oxidation-Reduction Polymorphism, Genetic RNA Stereoisomerism Steroid 16-alpha-Hydroxylase Steroid Hydroxylases Warfarin

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