Endotoxin modulates arachidonic acid-induced glycogenolysis in the perfused rat liver.

Kimura K, Moriyama M, Nishisako M, Kannan Y, Shiota M, Sugano T
Horm Metab Res. 1998 30 (4): 178-81

PMID: 9623630 · DOI:10.1055/s-2007-978862

Effects of endotoxin on arachidonic acid (AA)-induced hepatic glycogenolysis were examined in perfused rat liver. In normal rat liver, infusion of AA increased oxygen consumption and glucose production concurrently. In rats injected with lipopolysaccharide (LPS) 6 h before, AA increased glucose production but suppressed oxygen consumption. The changes in LPS-injected rat were abolished by a thromboxane (Tx) A2 receptor antagonist. The release of Tx B2 by AA increased after LPS-injection. These results suggest that priming of hepatic macrophage by endotoxin in vivo enhances Tx synthesis, resulting in modulating hepatic glycogenolysis.

MeSH Terms (12)

Animals Arachidonic Acid Lipopolysaccharides Liver Liver Glycogen Macrophages Male Oxygen Consumption Perfusion Rats Rats, Sprague-Dawley Receptors, Thromboxane

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