Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene.

Castillo SO, Baffi JS, Palkovits M, Goldstein DS, Kopin IJ, Witta J, Magnuson MA, Nikodem VM
Mol Cell Neurosci. 1998 11 (1-2): 36-46

PMID: 9608532 · DOI:10.1006/mcne.1998.0673

MeSH Terms (22)

Animals Biomarkers Brain Chemistry DNA-Binding Proteins Dopamine Exons Female Heterozygote Hypothalamus Levodopa Mice Mice, Inbred C57BL Mice, Neurologic Mutants Mutagenesis, Insertional Neurons Nuclear Receptor Subfamily 4, Group A, Member 2 Phenotype Pregnancy RNA, Messenger Substantia Nigra Transcription Factors Ventral Tegmental Area

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